Certified Tumor Registrar (CTR) Practice Exam

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Alpha-fetoprotein is a blood serum test specifically for which site?

Pancreas
Liver
Kidneys
Stomach

The correct answer is: Liver

Alpha-fetoprotein (AFP) is primarily associated with liver function as it is a marker for hepatocellular carcinoma, which is the most common type of liver cancer. In non-cancerous conditions such as liver cirrhosis or hepatitis, AFP levels may also increase, but its significance as a tumor marker is most pronounced in the diagnosis and monitoring of liver tumors. Elevated levels of AFP in the blood can indicate the presence of liver cancer, making it a useful tool in the early detection and management of this disease. While AFP might be present in other contexts, such as during pregnancy or in certain testicular germ cell tumors, its most clinically relevant application is in relation to liver pathology, confirming that the correct answer pertains to the liver.